Humoral immune system targets clonotypic antibody-associated hepatitis C virus
نویسندگان
چکیده
منابع مشابه
Humoral immune responsiveness in duck hepatitis B virus-infected ducks.
Immunofluorescence assays with fixed tissue sections were used to characterize antibody reactivity in sera obtained from duck hepatitis B virus-infected ducks. Under conditions of experimental infection, antibody to core antigen but not to surface antigen was detectable. A majority of the ducks infected at 8 days after hatching and a minority of those infected at 1 day after hatching showed a t...
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A hepatitis C virus (HCV) E2 variant encompassing amino acids 458 to 680 was expressed in Escherichia coli. The recombinant product (His-E2680) was immunoidentified as a 30-kD protein using the serum from a patient with chronic hepatitis C, and was purified using Ni-NTA chelate chromatography. When HCV-positive human sera were tested with the His-E2680 protein, 39% of them showed anti-E2 reacti...
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We have previously reported the production of hepatitis C virus-like particles (HCV-LP) using a recombinant baculovirus containing the cDNA of the HCV structural proteins (core, E1, and E2). These particles resemble the putative HCV virions and are capable of inducing strong and broad humoral and cellular immune responses in mice. Here we present evidence on the immunogenicity of HCV-LP and the...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2017
ISSN: 0022-1317,1465-2099
DOI: 10.1099/jgv.0.000659